Population pharmacokinetics and exposure–response relationship of the antituberculosis drug BTZ-043
We characterized the population PK/PD of BTZ-043 in trial participants with pulmonary TB. An exposure-response relationship was only apparent for the first 2 days on treatment, indicating the need for further dose-finding studies.
Authors
- Rodney Dawson (ORCID: https://orcid.org/0000-0001-9804-1588)
- Timothy D. McHugh (ORCID: https://orcid.org/0000-0003-4658-8594)
- Kim Narunsky
- Elin M. Svensson (ORCID: https://orcid.org/0000-0002-0093-6445)
- Patrick P. J. Phillips (ORCID: https://orcid.org/0000-0002-6336-7024)
- Julia Dreisbach (ORCID: https://orcid.org/0000-0001-6625-9857)
- Simon E. Koele (ORCID: https://orcid.org/0000-0002-7011-667X)
- Michael Höelscher (ORCID: https://orcid.org/0000-0002-7642-1835)
- Letícia Muraro Wildner (ORCID: https://orcid.org/0000-0003-2553-3244)
- Lindsey H. M. te Brake (ORCID: https://orcid.org/0000-0001-7727-2846)
- Veronique de Jager (ORCID: https://orcid.org/0000-0001-6389-5575)
- Rob E. Aarnoutse (ORCID: https://orcid.org/0000-0001-8925-969X)
- Norbert Heinrich
- Petra Gross-Demel
- Andreas H. Diacon
Institutions
- Uppsala University (SE)
- Radboud University Nijmegen (NL)
- University of Cape Town (ZA)
- University of California, San Francisco (US)
- Center for Environmental Health (US)
- University Medical Center (US)
- Radboud University Medical Center (NL)
- Helmholtz Zentrum München (DE)
- Task Applied Science (ZA)
- Lung Institute (US)
- Fraunhofer Institute for Translational Medicine and Pharmacology (DE)
- German Center for Infection Research (DE)
- South African Tuberculosis Vaccine Initiative (ZA)
- University College London (GB)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1093/jac/dkaf076
- Citations
- 3
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 4.19
Funders
- Deutsches Zentrum für Infektionsforschung
- Bundesministerium für Bildung und Forschung
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Bayerisches Staatsministerium für Wissenschaft und Kunst
- European and Developing Countries Clinical Trials Partnership