Platelet-derived Growth Factor Receptor-α as a Biomarker for Tongue Spindle Cell Carcinoma
MSC expansion was observed in cancer areas containing EpCAM-positive cells, implying that MSCs, especially PDGFRα-positive MSCs, may serve as cancer niche elements involved in epithelial-mesenchymal transition. Additional studies focusing on PDGFRα pharmacological targeting in SpCC will contribute to understanding of this tumor biology and developing new strategies for treating SpCC.
Authors
- Satoru Morikawa (ORCID: https://orcid.org/0000-0001-8859-2888)
- Taneaki Nakagawa (ORCID: https://orcid.org/0000-0003-1534-3244)
- Takehito Ouchi (ORCID: https://orcid.org/0000-0003-4258-2152)
- Seiji Asoda
Institutions
- Tokyo Dental College (JP)
- Keio University (JP)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-03-28
- DOI
- https://doi.org/10.21873/anticanres.17524
- Primary Topic
- Metastasis and carcinoma case studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00