p53-binding Protein Inhibits Intracellular Reactive Oxygen Species by Increasing the Expression of Metallothioneins
53BP1 plays a crucial role in maintaining ROS homeostasis by regulating genes involved in oxidative stress response. These results suggest that targeting ROS regulation through 53BP1-related pathways may provide novel insights into therapeutic strategies for diseases associated with oxidative stress.
Authors
- Seon‐Joo Park (ORCID: https://orcid.org/0000-0002-1825-1815)
- Jung‐Hee Lee (ORCID: https://orcid.org/0000-0002-1755-526X)
- Jae Woong Koh (ORCID: https://orcid.org/0000-0002-4523-4340)
- Cha Kyung Youn
Institutions
- Chosun University (KR)
- Gwangju University (KR)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-03-28
- DOI
- https://doi.org/10.21873/anticanres.17535
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Research Foundation
- National Research Foundation of Korea