Activation of<i>DCTN1-RET</i>Fusion Through Coiled-coil Domain as a Potential Target for RET Inhibitors
<i>DCTN1-RET</i> is a novel oncogenic fusion gene in thyroid cancer that promotes tumorigenesis through CC domain-mediated dimerization. It represents a potential therapeutic target for RET-specific inhibitors.
Authors
- Keiji Ishida
- Masanori Kato (ORCID: https://orcid.org/0009-0002-4918-8959)
- Shuichi Ohkubo (ORCID: https://orcid.org/0000-0001-9554-4534)
- Kunihiko Hayashi (ORCID: https://orcid.org/0000-0003-4648-3936)
- Yoshihiro Uto
Institutions
- Taiho Pharmaceutical (Japan) (JP)
- Tokushima University (JP)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-03-28
- DOI
- https://doi.org/10.21873/anticanres.17526
- Citations
- 1
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36