Isosakuranetin lnduces Autophagy and Apoptosis Through AMPK and PI3K/Akt Signaling in Human Leukemia Cells
Isosakuranetin induces apoptosis and autophagy in leukemia cells through the AMPK and PI3K/Akt pathways, as well as through JNK activation, with Beclin-1 playing a critical role in their crosstalk. These results highlight the potential of isosakuranetin as a therapeutic agent for leukemia.
Authors
- Ying‐Chih Huang (ORCID: https://orcid.org/0000-0002-9559-9428)
- Kuan-Ming Lai
- Chung-Jung Chou
- Ruo-Han Tseng
Institutions
- Dayeh University (TW)
- Changhua Christian Hospital (TW)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-03-28
- DOI
- https://doi.org/10.21873/anticanres.17531
- Citations
- 2
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.71