Activation of the γ-Aminobutyric Acid Receptor Type B Suppresses the Proliferation of Lung Adenocarcinoma Cells
GABA-B1 receptors were down-regulated in lung adenocarcinoma cells. Non-specific activation of the GABA-B receptor by baclofen significantly inhibited lung adenocarcinoma cell proliferation by cell cycle arrest and suppressed the GSK3 signaling pathway.
Authors
- Charupong Saengboonmee (ORCID: https://orcid.org/0000-0003-1476-1129)
- Kullanat Khawkhiaw
- Kanyarat Thithuan (ORCID: https://orcid.org/0000-0003-2267-210X)
- Yubin Zhou (ORCID: https://orcid.org/0000-0003-0067-2723)
Institutions
- University of Electronic Science and Technology of China (CN)
- Khon Kaen University (TH)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-03-28
- DOI
- https://doi.org/10.21873/anticanres.17533
- Citations
- 2
- Primary Topic
- Pharmacological Receptor Mechanisms and Effects
- Type
- article
- Field-Weighted Citation Impact
- 1.61