Metabolic Complications After Initiating BIC/FTC/TAF Versus DTG + 3TC in Antiretroviral-therapy-naive Adults With HIV: A Multicenter Prospective Cohort Study

In this nationwide cohort of ART-naive individuals, initiation of BIC/FTC/TAF or DTG + 3TC resulted in similar modest increases in weight and lipid levels after 96 weeks, with no significant differences in metabolic outcomes or clinical events. These findings suggest that the metabolic profile of TAF should not be a deciding factor when choosing between 2- and 3-drug ART regimens.

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Publication Details

Journal
Clinical Infectious Diseases
Published
2025-03-28
DOI
https://doi.org/10.1093/cid/ciae645
Citations
10
Primary Topic
HIV-related health complications and treatments
Type
article
Field-Weighted Citation Impact
22.53
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article

Metabolic Complications After Initiating BIC/FTC/TAF Versus DTG + 3TC in Antiretroviral-therapy-naive Adults With HIV: A Multicenter Prospective Cohort Study

Eugènia Negredo, Miguel Alberto de Zárraga Fernández, Javier Martínez‐Sanz, Marı́a Jesús Pérez-Elı́as et al.
10 citations
Clinical Infectious Diseases
HIV-related health complications and treatments
22.53
article

Metabolic Complications After Initiating BIC/FTC/TAF Versus DTG + 3TC in Antiretroviral-therapy-naive Adults With HIV: A Multicenter Prospective Cohort Study

Eugènia Negredo, Miguel Alberto de Zárraga Fernández, Javier Martínez‐Sanz, Marı́a Jesús Pérez-Elı́as, Miguel Suárez Robles, José Alcamı́, Carmen Elena Gómez Rodríguez, Santiago Moreno, Alejandro García García, Patricia González‐Ruano, Carlos Dueñas Gutiérrez
article en
10 citations

Abstract

In this nationwide cohort of ART-naive individuals, initiation of BIC/FTC/TAF or DTG + 3TC resulted in similar modest increases in weight and lipid levels after 96 weeks, with no significant differences in metabolic outcomes or clinical events. These findings suggest that the metabolic profile of TAF should not be a deciding factor when choosing between 2- and 3-drug ART regimens.

Clinical Infectious DiseasesVol. 81(2)
Universidad de Valladolid (ES), Universitat de Vic - Universitat Central de Catalunya (ES), Universitat Autònoma de Barcelona (ES), Consejo Superior de Investigaciones Científicas (ES), Universidad de Oviedo (ES), Universidad de Alcalá (ES), Instituto de Salud Carlos III (ES), Hospital Universitario San Agustín (ES), Universidad Europea (MX), Centro de Investigación Biomédica en Red (ES), Instituto Ramón y Cajal de Investigación Sanitaria (ES), Hospital Universitari Germans Trias i Pujol (ES), Hospital Clínico Universitario de Valladolid (ES), Hospital Universitario Infanta Sofía (ES), Hospital Universitario Ramón y Cajal (ES)
Good health and well-being
Openalex Percentile: Top 0%
HIV-related health complications and treatments
22.53
DOIOpen Access PDFOpenAlex
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