Plasma Biomarkers and Disease Prognosis in Mild Cognitive Impairment with Lewy Bodies
pTau181, GFAP, and NfL are associated with more rapid disease progression in MCI-LB and, with further validation, could be useful to support prognosis and stratification for clinical practice and treatment trials. Further work, including clinicopathological studies, is needed to understand the biological correlates of these markers in MCI-LB. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Rory Durcan (ORCID: https://orcid.org/0000-0002-8897-8737)
- John T. O’Brien (ORCID: https://orcid.org/0000-0002-0837-5080)
- Louise Allan (ORCID: https://orcid.org/0000-0002-8912-4901)
- Michael John Firbank (ORCID: https://orcid.org/0000-0002-9536-0185)
- Sarah Lawley (ORCID: https://orcid.org/0000-0002-4619-7211)
- Alan Thomas (ORCID: https://orcid.org/0000-0002-6667-9533)
- Kirsty Olsen (ORCID: https://orcid.org/0000-0001-5115-8324)
- Gemma Roberts (ORCID: https://orcid.org/0000-0002-6445-4023)
- Joanna Ciafone (ORCID: https://orcid.org/0000-0003-4339-2510)
- Calum A. Hamilton (ORCID: https://orcid.org/0000-0002-9812-3150)
- Amanda Heslegrave (ORCID: https://orcid.org/0000-0002-7290-6405)
- Nicola Barnett (ORCID: https://orcid.org/0000-0001-7596-7425)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Paul C. Donaghy (ORCID: https://orcid.org/0000-0001-7195-4846)
- Jahfer Hasoon (ORCID: https://orcid.org/0000-0002-0989-1175)
- John‐Paul Taylor (ORCID: https://orcid.org/0000-0001-7958-6558)
Institutions
- University College London Hospitals NHS Foundation Trust (GB)
- University of Wisconsin–Madison (US)
- University of Exeter (GB)
- University of Cambridge (GB)
- Sahlgrenska University Hospital (SE)
- University of California San Diego (US)
- UK Dementia Research Institute (GB)
- NIHR Newcastle Biomedical Research Centre (GB)
- University College London (GB)
- Newcastle University (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1002/mds.30181
- Citations
- 2
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Alzheimer's Society
- Weston Family Foundation
- UK Dementia Research Institute
- GE Healthcare
- Medical Research Council
- NIHR Newcastle Biomedical Research Centre
- UCLH Biomedical Research Centre
- NIHR Cambridge Biomedical Research Centre