Srsf3-Dependent APA Drives Macrophage Maturation and Limits Atherosclerosis
Our study reveals that Srsf3-dependent generation of long 3' untranslated region is required for efficient mitochondrial translation, which promotes mature phagocytic macrophage formation, thereby playing a protective role in atherosclerosis.
Authors
- Xian‐Wen Yang (ORCID: https://orcid.org/0000-0002-4967-0844)
- Lianping Cheng (ORCID: https://orcid.org/0009-0007-0941-5711)
- Yuhuai Xie (ORCID: https://orcid.org/0000-0001-7280-7098)
- Shenglai Chen
- Yuanyuan Wei (ORCID: https://orcid.org/0000-0003-0635-6879)
- Linfeng Wu (ORCID: https://orcid.org/0009-0007-9406-5786)
- Zhen Zhao (ORCID: https://orcid.org/0000-0002-4959-452X)
- Dejian Zhao (ORCID: https://orcid.org/0000-0002-2105-3799)
- Yaru Tian (ORCID: https://orcid.org/0000-0001-6315-1859)
- Yunhui Jia (ORCID: https://orcid.org/0009-0001-8019-1585)
- Xin Zhang (ORCID: https://orcid.org/0000-0001-9511-4737)
- Jiaxuan Yang
- Yihong Qin (ORCID: https://orcid.org/0009-0008-3095-416X)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Yale University (US)
- World Wide Web Consortium (US)
- Shanghai Ninth People's Hospital (CN)
- Zhongshan Hospital (CN)
- State Key Laboratory of Medical Neurobiology
Publication Details
- Journal
- Circulation Research
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1161/circresaha.124.326111
- Citations
- 6
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.78