Harnessing growth factors in endodontics

The primary objective of regenerative endodontic therapy is to re-establish the pulp-dentin complex in an immature permanent tooth with necrotic pulp that has been damaged by injury, inflammation and infection.The technique known as "cell homing," which effectively regenerates tissue at the site of tooth injury by attracting indigenous stem cells, is the foundation of this novel therapy.Many growth factors are involved in a complicated signalling network that controls this complex process.It is crucial to comprehend specific parts played by these growth factors throughout the regeneration and repair of dental tissue, such as orchestrating cell migration and differentiation.This review, summarizes the current understanding of the key growth factors, their involvement in dentin-pulp repair and regeneration and the challenges in completely regenerating the pulp-dentin complex.