Increasing cisplatin exposure promotes small-cell lung cancer transformation after a shift from glucose metabolism to fatty acid metabolism
This study provides the first evidence of cisplatin concentration-dependent metabolic reprogramming during NSCLC-to-SCLC transformation. We identified a phenotypic transition from NSCLC to SCLC accompanied by a metabolic shift from glucose to fatty acid metabolism, offering new insights into therapeutic strategies for treatmentresistant lung cancer.
Authors
- Chun Wang (ORCID: https://orcid.org/0000-0001-6636-0920)
- Jianguang Wang (ORCID: https://orcid.org/0000-0003-0597-021X)
- He Li (ORCID: https://orcid.org/0000-0003-3462-1377)
- Wenjun Liu (ORCID: https://orcid.org/0009-0009-3776-6580)
- Yumeng Wang (ORCID: https://orcid.org/0000-0001-9050-930X)
- Jing Lv (ORCID: https://orcid.org/0000-0002-4010-6622)
- Qiuyu Zhao
Institutions
- Liaoning University of Traditional Chinese Medicine (CN)
- ShanghaiTech University (CN)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1007/s00432-025-06164-3
- Citations
- 5
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- National Natural Science Foundation of China