Chlorogenic acid inhibits virulence and resistance gene transfer in outer membrane vesicles of carbapenem-resistant Klebsiella pneumoniae
These findings provide the first confirmation that CA can inhibit both the virulence and the transmission of drug resistance in KOMV-MEM. This underscores the potential of CA treatment as a promising antimicrobial strategy against CRKp infection.
Authors
- Haixia Du (ORCID: https://orcid.org/0000-0002-6566-1577)
- Jiehong Yang (ORCID: https://orcid.org/0000-0002-2758-0485)
- Jiayang Wan
- Daojun Yu (ORCID: https://orcid.org/0000-0003-0855-7420)
- W.P. Wang
- Haitong Wan (ORCID: https://orcid.org/0000-0003-4459-8246)
- Huifen Zhou
Institutions
- Zhejiang Chinese Medical University (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-31
- DOI
- https://doi.org/10.3389/fphar.2025.1562096
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.18