Pharmacokinetics and Safety of Levofloxacin for Treatment of Rifampicin-Resistant Tuberculosis During Pregnancy and the Postpartum Period: Results from IMPAACT P1026s
Levofloxacin AUC<sub>0-12</sub> was lower in the second trimester than the third trimester of pregnancy and the postpartum period, but exposures overall were within target ranges. Further research is warranted to explore the clinical significance of these findings.
Authors
- Marije Van Schalkwyk (ORCID: https://orcid.org/0000-0003-2679-901X)
- Anneke Catharina Hesseling (ORCID: https://orcid.org/0000-0001-9399-9834)
- Ahizechukwu Chigoziem Eke (ORCID: https://orcid.org/0000-0002-0070-9840)
- Petra De Koker
- James S. Ngocho (ORCID: https://orcid.org/0000-0001-6242-9863)
- David E. Shapiro (ORCID: https://orcid.org/0009-0008-6051-7745)
- Lubbe Wiesner (ORCID: https://orcid.org/0000-0002-9070-8699)
- Jennifer Hughes (ORCID: https://orcid.org/0000-0002-5349-9509)
- Mauricio Pinilla
- Kevin Knowles
- Kristina M. Brooks (ORCID: https://orcid.org/0000-0002-3832-8699)
- Nahida Chakhtoura
- Brookie M. Best (ORCID: https://orcid.org/0000-0001-8569-2293)
- Kathleen George
- Eric H. Decloedt (ORCID: https://orcid.org/0000-0003-1815-5150)
- Lee Fairlie (ORCID: https://orcid.org/0000-0001-5327-1734)
- Alice Marie Stek
- Renee Browning (ORCID: https://orcid.org/0000-0003-3839-9478)
- Mark Mirochnick
Institutions
- Boston University (US)
- University of Southern California (US)
- Family Health International 360 (US)
- National Institutes of Health (US)
- Desmond Tutu HIV Foundation (ZA)
- Johns Hopkins University (US)
- University of Cape Town (ZA)
- University of the Witwatersrand (ZA)
- Stellenbosch University (ZA)
- Johns Hopkins Medicine (US)
- Tygerberg Hospital (ZA)
- University of California San Diego (US)
- Rady Children's Hospital-San Diego (US)
- Cancer Research And Biostatistics (US)
- National Institute of Allergy and Infectious Diseases (US)
- Kilimanjaro Christian Medical Centre (TZ)
- Frontier Science & Technology Research Foundation, Inc. (US)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1007/s40262-025-01498-0
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- International Maternal Pediatric Adolescent AIDS Clinical Trials Network
- Universiteit Stellenbosch
- University of Cape Town
- National Institute of Mental Health
- National Institute of Allergy and Infectious Diseases
- Eunice Kennedy Shriver National Institute of Child Health and Human Development