Mendelian randomization study highlights the role of hematological traits on Type-2 diabetes mellitus in African ancestry individuals
These findings indicate that hematological traits may differentially play a role in the development of T2D and be affected by T2D. However, further research is needed to validate and explore the biological pathways and mechanisms involved in these associations.
Authors
- Dorothea Nitsch (ORCID: https://orcid.org/0000-0001-5767-248X)
- Chisom Soremekun (ORCID: https://orcid.org/0009-0005-9533-0102)
- Eleftheria Zeggini (ORCID: https://orcid.org/0000-0003-4238-659X)
- Daudi Jjingo (ORCID: https://orcid.org/0000-0003-1685-9234)
- David Patrick Kateete (ORCID: https://orcid.org/0000-0001-8075-3069)
- Moffat Nyirenda (ORCID: https://orcid.org/0000-0003-2120-4806)
- Dipender Gill (ORCID: https://orcid.org/0000-0001-7312-7078)
- Chiara Batini (ORCID: https://orcid.org/0000-0002-7140-2985)
- Harald Grallert (ORCID: https://orcid.org/0000-0002-6876-9655)
- Opeyemi Soremekun (ORCID: https://orcid.org/0000-0002-7608-3848)
- Tinashe Chikowore (ORCID: https://orcid.org/0000-0002-6743-751X)
- Oyekanmi Nash (ORCID: https://orcid.org/0000-0002-0796-7834)
- Segun Fatumo (ORCID: https://orcid.org/0000-0003-4525-3362)
- Annette Peters (ORCID: https://orcid.org/0000-0001-6645-0985)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- University of Leicester (GB)
- Queen Mary University of London (GB)
- University of the Witwatersrand (ZA)
- University Hospitals of Leicester NHS Trust (GB)
- TUM Klinikum (DE)
- Helmholtz Zentrum München (DE)
- London School of Hygiene & Tropical Medicine (GB)
- Wits University Donald Gordon Medical Centre (ZA)
- Infectious Diseases Institute (UG)
- Deutsches Diabetes-Zentrum e.V. (DE)
- Nigeria Centre for Disease Control (NG)
- German Center for Diabetes Research (DE)
- Heinrich Heine University Düsseldorf (DE)
- Imperial College London (GB)
- Technical University of Munich (DE)
- Makerere University (UG)
- Ludwig-Maximilians-Universität München (DE)
- Uganda Virus Research Institute (UG)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-31
- DOI
- https://doi.org/10.3389/fphar.2025.1436972
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Office of Research and Development