Physiologically based pharmacokinetic model of sodium-glucose cotransporter 2 inhibitors predicted pharmacokinetics and pharmacodynamics to explore dosage regimen for patients with type 2 diabetes mellitus and renal insufficiency
This study provided a scientific basis for optimizing the dosage regimen in T2DM patients with renal insufficiency.
Authors
- Guimu Guo
- Wanhong Wu (ORCID: https://orcid.org/0000-0001-7096-7821)
- Jianwen Xu (ORCID: https://orcid.org/0000-0002-8095-591X)
- Ke Meng (ORCID: https://orcid.org/0000-0002-9213-7439)
- Chengjie Ke (ORCID: https://orcid.org/0009-0006-4160-1875)
- Cuihong Lin (ORCID: https://orcid.org/0000-0001-6043-9187)
- Pinfang Huang
- Jiarui Chen (ORCID: https://orcid.org/0000-0003-2005-288X)
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-31
- DOI
- https://doi.org/10.3389/fphar.2025.1520268
- Citations
- 3
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 3.88