Molecular recognition and potentiometric determination of neostigmine and pyridostigmine by a methylene-bridged naphthotube
A macrocyclic arene featuring rigid bis-naphthalene possesses a remarkable ability to strongly bind neostigmine (<i>K</i> <sub>a</sub> = 2.7 × 10<sup>4</sup> M<sup>-1</sup>) and pyridostigmine (<i>K</i> <sub>a</sub> = 2.2 × 10<sup>5</sup> M<sup>-1</sup>) within its deep cavity. This facilitates the host as a potential ionophore for the potentiometric determination of neostigmine and pyridostigmine with low detection limits of 1.0 μM, highlighting its promising applications in pharmaceutical analysis.
Authors
- Liu‐Pan Yang (ORCID: https://orcid.org/0000-0003-4983-966X)
- Dehua Liao (ORCID: https://orcid.org/0000-0001-8376-1419)
- Lili Wang (ORCID: https://orcid.org/0009-0005-6027-0218)
- Yanfang Wang (ORCID: https://orcid.org/0009-0005-4890-0651)
- Wen‐Jie Chen (ORCID: https://orcid.org/0000-0002-9428-7828)
- Jinyang Wu
Institutions
- Central South University (CN)
- Zhejiang University of Science and Technology (CN)
- Hunan Cancer Hospital (CN)
- Zhejiang University (CN)
- University of South China (CN)
Publication Details
- Journal
- RSC Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d4ra09021g
- Citations
- 1
- Primary Topic
- Analytical Chemistry and Sensors
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province
- University of South China