Palladium-catalyzed regio- and enantio-selective trifluoromethylated allylic alkylation of diphenylphosphine oxides
The first convenient method for the allylic alkylation of diphenylphosphine oxides catalyzed by palladium has been designed and developed, affording various chiral allylphosphine oxides bearing CF<sub>3</sub> groups with exclusive regio-selectivity and excellent enantioselective control. The reaction was performed in one pot under relatively mild reaction conditions using "easy-to-prepare" starting materials and relatively inexpensive chiral bis(phosphines) ligands. Further transformations of a representative product confirm the feasibility and potential applications of our synthetic strategies. In conclusion, this study provides a valuable method method for synthesizing chiral molecules bearing CF<sub>3</sub> and allylphosphine oxide.
Authors
- Jingping Qü (ORCID: https://orcid.org/0000-0002-7576-0798)
- Shuaibo Zhang
- Jinfeng Zhao (ORCID: https://orcid.org/0000-0003-2127-0870)
- Bangzhong Wang
- Yuhan Zhou (ORCID: https://orcid.org/0000-0002-1860-8669)
- Yunzhe Liu (ORCID: https://orcid.org/0000-0002-8946-9969)
- Luyang Sun (ORCID: https://orcid.org/0009-0000-1138-575X)
Institutions
- Dalian University of Technology (CN)
- Dalian University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob00096c
- Citations
- 1
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.79