C1Q+ TPP1+ macrophages promote colon cancer progression through SETD8-driven p53 methylation
These findings suggest that p53<sup>K382me1</sup> may be an early step in tumor initiation, especially in inflammation-induced CRC, and could serve as a functional biomarker and therapeutic target in adjuvant setting for advanced CRCs.
Authors
- Francesco Verona (ORCID: https://orcid.org/0000-0001-6226-4624)
- Kate Brown (ORCID: https://orcid.org/0009-0007-5006-8379)
- Veronica Veschi (ORCID: https://orcid.org/0000-0002-6379-7366)
- Alice Turdo (ORCID: https://orcid.org/0000-0002-6152-4903)
- Simone Di Franco (ORCID: https://orcid.org/0000-0002-6217-2161)
- Chiara Modica (ORCID: https://orcid.org/0000-0002-7000-5216)
- Ornella Roberta Brancato (ORCID: https://orcid.org/0000-0002-2783-0720)
- Melania Lo Iacono (ORCID: https://orcid.org/0000-0002-9292-327X)
- Miriam Gaggianesi (ORCID: https://orcid.org/0000-0002-7810-856X)
- Pierre Martine (ORCID: https://orcid.org/0009-0000-5984-1101)
- Caterina D’Accardo (ORCID: https://orcid.org/0000-0003-1171-8678)
- Ettore Appella (ORCID: https://orcid.org/0000-0003-0569-9722)
- Elisabetta Sciacca (ORCID: https://orcid.org/0000-0001-7525-1558)
- Peter Fitzgerald (ORCID: https://orcid.org/0000-0001-8769-0507)
- Vincenzo Luca Lentini (ORCID: https://orcid.org/0000-0002-3679-3968)
- Paola Bianca (ORCID: https://orcid.org/0000-0002-9172-0809)
- Matilde Todaro (ORCID: https://orcid.org/0000-0001-8686-8043)
- David López-Pérez (ORCID: https://orcid.org/0000-0002-6443-6773)
- Giuseppe Giannini (ORCID: https://orcid.org/0000-0002-7127-985X)
- Gaetana Porcelli (ORCID: https://orcid.org/0000-0002-7991-407X)
- Giorgio Stassi (ORCID: https://orcid.org/0000-0002-1016-9059)
- Laura Rosa Mangiapane (ORCID: https://orcid.org/0000-0003-4186-0157)
- Isabella Sperduti (ORCID: https://orcid.org/0000-0001-5115-3099)
- Sebastiano Di Bella (ORCID: https://orcid.org/0000-0001-7161-303X)
Institutions
- National Institutes of Health (US)
- Queen Mary University of London (GB)
- Ospedale Vincenzo Cervello (IT)
- National Cancer Institute (US)
- Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo (IT)
- William Harvey Research Institute (GB)
- Istituto Pasteur (IT)
- Sapienza University of Rome (IT)
- University of Palermo (IT)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1186/s12943-025-02293-y
- Citations
- 15
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 12.09
Funders
- Ministero della Salute
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Ministero dell'Università e della Ricerca