Doxycycline inhibits MMP-2 retinal activity and modulates the angiogenic process in vitro and in vivo
Our results lead to propose a possible DXC mechanism for inhibition of angiogenesis through the modulation of MMPs involving the VEGF/PEDF balance. These findings underscore the potential repositioning of DXC as a new possibility for treating ocular proliferative diseases.
Authors
- José D. Luna (ORCID: https://orcid.org/0000-0002-4203-7667)
- María V. Vaglienti (ORCID: https://orcid.org/0009-0007-0735-5356)
- Mariana Belén Joray
- Paula V. Subirada
- María Lina Formica (ORCID: https://orcid.org/0000-0001-7225-0998)
- Marı́a C. Sánchez (ORCID: https://orcid.org/0000-0003-4760-8518)
- Pablo F. Barcelona (ORCID: https://orcid.org/0000-0001-8248-2282)
- Santiago Daniel Palma
- Yolanda Fernández (ORCID: https://orcid.org/0000-0002-8028-3965)
- María Constanza Paz
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Universidad Nacional de Córdoba (AR)
- Research Centre in Biological Chemistry of Córdoba (AR)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-03-31
- DOI
- https://doi.org/10.3389/fcell.2025.1561250
- Citations
- 2
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.41
Funders
- Universidad Nacional de Córdoba
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación