Restoration of colonic barrier function by tofacitinib in experimental colitis: anti-inflammatory effects and decreased expression of claudins-2 and claudin-15
JAK inhibition by tofacitinib restored colonic barrier function through antiinflammatory effects and decreased claudin-2 and claudin-15 expressions.
Authors
- Alexandre Havt (ORCID: https://orcid.org/0000-0002-4546-2976)
- Humberto Barbosa da Costa Filho (ORCID: https://orcid.org/0000-0003-2085-6773)
- Thiago M. Sales (ORCID: https://orcid.org/0000-0001-7984-0480)
- Pedro Marcos Gomes Soares (ORCID: https://orcid.org/0000-0003-0606-2539)
- Marco Clementino (ORCID: https://orcid.org/0000-0002-0628-8047)
- Suliana Mesquita Paula (ORCID: https://orcid.org/0000-0002-0750-5365)
- Marcellus Henrique Loiola Ponte de Souza (ORCID: https://orcid.org/0000-0003-2376-3433)
- G Araujo (ORCID: https://orcid.org/0000-0002-0382-8327)
Institutions
- Universidade Federal do Ceará (BR)
Publication Details
- Journal
- Intestinal Research
- Published
- 2025-03-31
- DOI
- https://doi.org/10.5217/ir.2024.00186
- Citations
- 2
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.68