The insula represents a key neurobiological pain hub in psoriatic arthritis
For the first time, we demonstrate objectively that nociceptive and nociplastic pain mechanisms co-exist in PsA. PsA pain cannot be assumed to be only nociceptive in origin and screening for nociplastic pain in the future will inform supplementary analgesic approaches.
Authors
- Chelsea Kaplan (ORCID: https://orcid.org/0000-0001-9324-655X)
- Daniel J. Clauw (ORCID: https://orcid.org/0000-0002-8114-7818)
- Steven E. Harte (ORCID: https://orcid.org/0000-0002-2929-8694)
- Kristian Stefanov (ORCID: https://orcid.org/0000-0003-0117-1744)
- Richard E. Harris (ORCID: https://orcid.org/0000-0002-2067-8447)
- Carl S. Goodyear (ORCID: https://orcid.org/0000-0001-5926-5941)
- Flavia Sunzini (ORCID: https://orcid.org/0000-0003-0775-9960)
- John McLean (ORCID: https://orcid.org/0000-0003-1469-5889)
- Salim Al‐Wasity (ORCID: https://orcid.org/0000-0002-9134-1374)
- Stefan Siebert (ORCID: https://orcid.org/0000-0002-1802-7311)
- Neil Basu (ORCID: https://orcid.org/0000-0003-4246-3145)
- Gordon D. Waiter (ORCID: https://orcid.org/0000-0002-5313-9845)
- Andrew Schrepf (ORCID: https://orcid.org/0000-0003-4291-0320)
- Noah Waller (ORCID: https://orcid.org/0000-0002-1284-218X)
Institutions
- University of Aberdeen (GB)
- University of California, Irvine (US)
- University of Michigan (US)
- NHS Greater Glasgow and Clyde (GB)
- Samueli Institute (US)
- University of Glasgow (GB)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1186/s13075-025-03526-7
- Citations
- 2
- Primary Topic
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Versus Arthritis