Cardiometabolic profile and 24-hour blood pressure monitoring parameters in pregnant women with white coat hypertension

Objective: to perform a comparative assessment of cardiometabolic parameters and 24-h blood pressure monitoring indicators in pregnant women with white-coat hypertension and normal blood pressure. Materials and methods: this prospective cohort study included 88 pregnant women aged 18–44 years: group 1 (study group) – 44 women with white coat hypertension (aged 32 ± 5.7 years); group 2 (comparison group) – 44 women with normal blood pressure (aged 28 ± 5.9 years). Results: the most significant differences between groups 1 and 2 were observed in serum glucose, low-density lipoprotein cholesterol, and uric acid. In assessing cardiometabolic risk factors, significant differences were found only in the frequency of abdominal obesity. Only pregnant women with white-coat hypertension had a history of preeclampsia and gestational hypertension. The mean daytime and nighttime systolic blood pressure (SBP) and diastolic blood pressure (DBP), daytime variability of SBP, daytime time index of SBP, daytime and nighttime time index of DBP, daytime mean heart rate, the rate of morning rise of SBP and DBP, as well as a high frequency of non-dippers were significantly higher in pregnant women in group 1 compared to group 2. Conclusion: 24-h blood pressure monitoring up to 20 weeks of pregnancy allows not only recognition of white-coat hypertension but also identification of a high-risk group for more careful monitoring of pregnant women with this hypertension phenotype.