Esketamine mitigates systemic inflammation via modulating phenotypic transformation of monocytes in patients undergoing thoracic surgery
Esketamine mitigates surgery-triggered inflammation by suppressing monocyte/macrophage proinflammatory activity and TNF-α release, offering dual anesthetic and immunomodulatory benefits.
Authors
- Lin Yang (ORCID: https://orcid.org/0000-0002-7594-3770)
- Weiyun Shen (ORCID: https://orcid.org/0000-0003-2960-7319)
- Yan Yan (ORCID: https://orcid.org/0009-0005-5892-9992)
- Zhijian Li (ORCID: https://orcid.org/0000-0002-3837-7001)
- Junmei Xu (ORCID: https://orcid.org/0000-0003-0925-0789)
- Wenjuan Zhang (ORCID: https://orcid.org/0000-0002-8815-2687)
Institutions
- Central South University (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1016/j.lfs.2025.123594
- Citations
- 3
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 4.41