Redox-neutral-photocatalyzed decarboxylative radical addition/acyl migration cascade process: modular access to functionalized α-(hetero)aryl-α-aminoketones

Herein, using reductive radical-polar crossover as a key process, a robust and practical protocol for the N → C acyl migration reaction has been successfully developed. A variety of enamides could react with carboxylic acids for modular access to α-(hetero)aryl-α-aminoketones enabled by redox-neutral photocatalysis. This decarboxylative radical addition/acyl migration cascade process features a broad substrate scope, good functional compatibility, and mild reaction conditions.