Inhaled sedation versus propofol in respiratory failure in the ICU (INSPiRE-ICU2): study protocol for a multicenter randomized controlled trial
The INSPiRE-ICU2 trial will help determine the potential role of isoflurane for sedation of ventilator-dependent adult patients in the ICU. Key trial design features, including adoption of the estimand framework and blinded assessments of sedation depth, pain, and cognitive recovery, will ensure a rigorous evaluation of isoflurane for ICU sedation. TRIAL REGISTRATION: ClinicalTrials.gov, NCT05327296. First registered on April 5, 2022.
Authors
- Brian O’Gara (ORCID: https://orcid.org/0000-0002-3868-7499)
- Alexis Serra (ORCID: https://orcid.org/0000-0001-7366-1350)
- Daniel Talmor
- Robert L. Owens (ORCID: https://orcid.org/0000-0002-6515-6204)
- Jeremy R. Beitler (ORCID: https://orcid.org/0000-0003-0797-2374)
- Peter Sackey
- Pauline K. Park (ORCID: https://orcid.org/0000-0002-5972-4340)
- Joshua A. Englert (ORCID: https://orcid.org/0000-0002-1257-2239)
- Steven Y. Chang (ORCID: https://orcid.org/0000-0002-7365-5265)
- Alisha Sachdev
- Ida Sverud
Institutions
- Rush University Medical Center (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- University of California, Los Angeles (US)
- University of Michigan (US)
- The Ohio State University Wexner Medical Center (US)
- University of California System (US)
- Karolinska Institutet (SE)
- University of California San Diego (US)
- New York University (US)
Publication Details
- Journal
- Trials
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1186/s13063-025-08791-0
- Citations
- 2
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.09