Allostatic load, a measure of cumulative physiological stress, impairs brain structure but not β-accumulation in older adults: an exploratory study
AL is linked to structural brain integrity in aging- and stress-sensitive regions but not with AD-related markers (<i>β</i>-amyloid load) and only in two AD-sensitive brain regions in older adults. These results highlight the potential interest of AL as a sensitive index of stress-induced brain aging.
Authors
- Denis Vivien (ORCID: https://orcid.org/0000-0002-7636-2185)
- Gaël Chételat (ORCID: https://orcid.org/0000-0002-4889-7932)
- Séverine Fauvel
- Vincent de La Sayette (ORCID: https://orcid.org/0000-0003-0663-092X)
- Natalie L. Marchant (ORCID: https://orcid.org/0000-0003-0669-6910)
- Géraldine Poisnel (ORCID: https://orcid.org/0000-0001-7943-1281)
- Olga Klimecki (ORCID: https://orcid.org/0000-0003-0757-7761)
- Florence Mézenge
- Laurent Coulbault
- Léa Chauveau (ORCID: https://orcid.org/0000-0001-5965-3194)
- Fabienne Collette (ORCID: https://orcid.org/0000-0001-9288-9756)
- Francesca Felisatti
- Brigitte Landeau (ORCID: https://orcid.org/0000-0002-0814-3714)
- Sacha Haudry
- Anne Chocat
- Cassandre Palix (ORCID: https://orcid.org/0000-0001-8736-5261)
- Oriane Hébert
Institutions
- Centre Hospitalier Universitaire de Caen Normandie (FR)
- University College London (GB)
- Université de Caen Normandie (FR)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-03-31
- DOI
- https://doi.org/10.3389/fnagi.2025.1508677
- Citations
- 5
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 5.56