Pan-cancer analysis of CHRDL1 expression and its mechanistic role in inhibiting EMT via the TGF-β pathway in lung adenocarcinoma
CHRDL1 exerts a complex influence on cancer development and progression, particularly in LUAD, by impacting tumor progression, immune regulation, chemosensitivity, and EMT regulation. This research offers valuable insights into the overarching mechanisms of cancer progression and aids in the discovery of innovative therapeutic strategies for LUAD treatment.
Authors
- Suxin Jiang
- Honghong Dong (ORCID: https://orcid.org/0000-0002-0391-4727)
- Yahui Tian (ORCID: https://orcid.org/0009-0006-2004-554X)
- Shaowei Xin (ORCID: https://orcid.org/0000-0002-7606-134X)
- Yong Han (ORCID: https://orcid.org/0000-0002-5325-1722)
- Huaiyu Wang (ORCID: https://orcid.org/0000-0002-9093-8793)
- Yujie Guo (ORCID: https://orcid.org/0000-0002-2379-0725)
- Zitong Wan (ORCID: https://orcid.org/0009-0004-2527-8997)
Institutions
- China Medical University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-03-31
- DOI
- https://doi.org/10.3389/fcell.2025.1557761
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94