Platelet secretions exert anti-inflammatory effects in vitro on neutrophils and uterine epithelia in cattle: a possible role in amplifying the uterine immune network toward pregnancy
Our findings reveal for the first time that platelet secretions directly act on PMNs and BEECs <i>in vitro</i>, thereby assisting the uterine immune network to shift anti-inflammatory environment toward pregnancy. The present study can explain, in part, the successful applications of platelet derivatives in reproductive medicine.
Authors
- Mohamed Samy Yousef (ORCID: https://orcid.org/0000-0001-8204-6931)
- Shingo Haneda (ORCID: https://orcid.org/0000-0001-6620-9825)
- Kazuya Kusama (ORCID: https://orcid.org/0000-0002-9120-0475)
- Masayuki Shimada (ORCID: https://orcid.org/0000-0002-6500-2088)
- Akio Miyamoto (ORCID: https://orcid.org/0000-0003-0401-7304)
- Ihshan Akthar (ORCID: https://orcid.org/0000-0003-4556-7046)
- Kazuhiko Imakawa (ORCID: https://orcid.org/0000-0002-3798-3560)
- Dongxue Ma (ORCID: https://orcid.org/0000-0003-1140-3676)
Institutions
- Hiroshima University (JP)
- Tokyo University of Pharmacy and Life Sciences (JP)
- Obihiro University of Agriculture and Veterinary Medicine (JP)
- Assiut University (EG)
- Kyushu Tokai University (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-31
- DOI
- https://doi.org/10.3389/fimmu.2025.1560996
- Citations
- 1
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.80