Increased TIGIT expression correlates with impaired NK cell function in diffuse large B-cell lymphoma
Dysregulated expression of TIGIT and its family molecules on NK cells contributes to NK cell dysfunction and promotes tumor immune escape in DLBCL. These findings highlight TIGIT as a promising therapeutic target for restoring NK cell-mediated antitumor immunity in DLBCL.
Authors
- Hui Lü (ORCID: https://orcid.org/0000-0002-5921-1043)
- Huafang Wang (ORCID: https://orcid.org/0000-0001-6226-072X)
- Xiaoyan Zhao (ORCID: https://orcid.org/0000-0001-8942-5061)
- Liqiong Liu (ORCID: https://orcid.org/0000-0002-2680-4360)
- Lu Zhang (ORCID: https://orcid.org/0000-0001-9049-8807)
Institutions
- Union Hospital (HK)
- Guangdong Medical College (CN)
- Shenzhen Sixth People's Hospital (CN)
- Shenzhen University Health Science Center (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-03-31
- DOI
- https://doi.org/10.3389/fonc.2025.1551061
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.80