The efficacy and safety of ceftazidime/avibactam or polymyxin B based regimens for carbapenem-resistant Pseudomonas aeruginosa infection: a multicenter real-world and propensity score-matched study
In conclusion, CAZ/AVI-based regimens demonstrated superior efficacy in clearing <i>CRPA</i> compared to PMB-based regimens. Furthermore, several factors associated with AKI and mortality in <i>CRPA</i>-infected patients were identified, highlighting the need for further research to optimize treatment strategies.
Authors
- Jian Qu (ORCID: https://orcid.org/0000-0002-6694-2450)
- Wen-Ming Long
- Qin Hu (ORCID: https://orcid.org/0000-0002-5910-7596)
- Ying Chen (ORCID: https://orcid.org/0000-0002-6412-0568)
- Qing Wan (ORCID: https://orcid.org/0000-0003-4588-7592)
- Wei-Xin Xu
- Qiang Qu (ORCID: https://orcid.org/0000-0002-1661-3261)
- Xiaoli Wu (ORCID: https://orcid.org/0000-0003-1601-731X)
- Tiantian Xu (ORCID: https://orcid.org/0000-0002-9175-3264)
- Yue Luo
Institutions
- Central South University (CN)
- Nanchang University (CN)
- Changsha Medical University (CN)
- Wuhan University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Renmin Hospital of Wuhan University (CN)
- Liuyang City Maternal and Child Health Hospital (CN)
- Xian Yang Central Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- Xiangya Hospital Central South University (CN)
- First Affiliated Hospital of Nanchang University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-31
- DOI
- https://doi.org/10.3389/fphar.2025.1533952
- Citations
- 10
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 5.91