The dual role of CXCL9/SPP1 polarized tumor-associated macrophages in modulating anti-tumor immunity in hepatocellular carcinoma
Our research sheds light on the regulatory roles of SPP1<sup>+</sup> TAMs and CXCL9<sup>+</sup> TAMs in the micro-environment and provides new therapeutic targets or insights for the reprogramming of targeted macrophages in HCC.
Authors
- Hao Huang (ORCID: https://orcid.org/0000-0002-5570-6145)
- Rongxin Zhang (ORCID: https://orcid.org/0000-0002-4083-374X)
- Zhihui Zhang (ORCID: https://orcid.org/0000-0001-6326-7624)
- Yu Gu (ORCID: https://orcid.org/0000-0002-0411-0990)
- Wenyong Zhu (ORCID: https://orcid.org/0000-0003-3907-5782)
- Xiao Sun (ORCID: https://orcid.org/0000-0003-1048-7775)
- Hongjia Liu (ORCID: https://orcid.org/0000-0003-3102-0082)
- Nan Weng
Institutions
- Nanjing University of Chinese Medicine (CN)
- State Key Laboratory of Digital Medical Engineering (CN)
- Southeast University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-31
- DOI
- https://doi.org/10.3389/fimmu.2025.1528103
- Citations
- 6
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.78