Rethinking <scp>HIV</scp> treatment: How non‐<scp>integrase strand</scp> regimens may hold the key to better immune health

This study challenges the assumption that INSTI-based ARV regimens are universally superior, suggesting that non-INSTI therapies may better preserve immune function by reducing PD-1 expression. These findings highlight the potential benefits of non-INSTI regimens in improving long-term clinical outcomes in HIV treatment, warranting further research.

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Publication Details

Journal
HIV Medicine
Published
2025-03-28
DOI
https://doi.org/10.1111/hiv.70020
Citations
1
Primary Topic
HIV-related health complications and treatments
Type
article
Field-Weighted Citation Impact
2.25
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article

Rethinking HIV treatment: How non‐integrase strand regimens may hold the key to better immune health

Miłosz Parczewski, Kaja Scheibe, Karolina Skonieczna‐Żydecka, Paulina Niedźwiedzka‐Rystwej et al.
1 citations
HIV Medicine
HIV-related health complications and treatments
2.25
article

Rethinking HIV treatment: How non‐integrase strand regimens may hold the key to better immune health

Miłosz Parczewski, Kaja Scheibe, Karolina Skonieczna‐Żydecka, Paulina Niedźwiedzka‐Rystwej, Rafał Hrynkiewicz, Karol Serwin, Filip Lewandowski, Bogusz Aksak‐Wąs, Franciszek Lenkiewicz
article en
1 citations

Abstract

This study challenges the assumption that INSTI-based ARV regimens are universally superior, suggesting that non-INSTI therapies may better preserve immune function by reducing PD-1 expression. These findings highlight the potential benefits of non-INSTI regimens in improving long-term clinical outcomes in HIV treatment, warranting further research.

HIV MedicineVol. 26(6)
University of Szczecin (PL), Pomeranian Medical University (PL)
Reduced inequalities
Openalex Percentile: Top 16%
HIV-related health complications and treatments
2.25
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Rethinking <scp>HIV</scp> treatment: How non‐<scp>integrase strand</scp> regimens may hold the key to better immune health — Miłosz Parczewski, Kaja Scheibe, et al. · HIV Medicine (2025) | TGRS Research Map | TGRS