Serum phospholipids and sphingolipids are linked to early-stage osteoarthritis by lipidomic profiling
The significant lipidomic alterations that were detected at an average Outerbridge score of less than 2 suggest that certain serum PLs may serve as indicators for monitoring the early stages of OA even before radiologic detection is possible. With 10% of PL species elevated only in OA serum, our data implicate the existence of a systemic response that parallels the local lipid metabolic response to OA.
Authors
- Christiane Hild
- Gerrit Eichner (ORCID: https://orcid.org/0000-0001-9523-5520)
- Gerhard Liebisch (ORCID: https://orcid.org/0000-0003-4886-0811)
- Jürgen Steinmeyer (ORCID: https://orcid.org/0000-0002-4053-503X)
- Markus Rickert (ORCID: https://orcid.org/0000-0001-7681-9918)
Institutions
- Justus-Liebig-Universität Gießen (DE)
- University Hospital Regensburg (DE)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1186/s13075-025-03537-4
- Citations
- 4
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 6.67
Funders
- European Commission