Leukocytosis and a Rare Gallbladder Sarcomatoid Carcinoma: A Case Report

Abstract Gallbladder sarcomatoid carcinoma is a rare and aggressive malignancy, often presenting with abdominal symptoms. The tumor typically has high metastatic potential, even after surgical resection. The paraneoplastic leukemoid reaction is an uncommon manifestation of solid tumors. Here, we report a case of a female patient who presented with abdominal fullness, weight loss, and unexplained afebrile leukocytosis. She was diagnosed with gallbladder sarcomatoid carcinoma following surgery and experienced a rapid recurrence of leukocytosis upon tumor relapse. This report highlights the unique clinical presentation of the patient and also discusses the treatment approach and decision-making process involved in her management.