Multi-omics analysis of host-microbiome interactions in a mouse model of congenital hepatic fibrosis
This study identifies distinct metabolic and microbiome profiles in Pkhd1<sup>del3-4/del3-4</sup> mice. Multi-omics analysis effectively differentiates CHF mice from controls and identified potential biomarkers. These findings indicate that gut microbiota and metabolites are integral to the pathogenesis of CHF, offering novel insights into the disease mechanism.
Authors
- Xiaoxin Yin (ORCID: https://orcid.org/0009-0009-5707-8558)
- Chuanlong Zhu (ORCID: https://orcid.org/0000-0001-6557-1654)
- Mengfan Jiao
- Xilin Hou (ORCID: https://orcid.org/0000-0003-0776-2959)
- Qingling Chen (ORCID: https://orcid.org/0009-0008-0063-2952)
- Ye Sun (ORCID: https://orcid.org/0000-0001-5234-3775)
- Zixing Dai
- Yuwen Li (ORCID: https://orcid.org/0009-0000-9359-8416)
- Rui Liu (ORCID: https://orcid.org/0009-0002-6467-8577)
Institutions
- Shandong Provincial Hospital (CN)
- Jiangsu Province Hospital (CN)
- Shandong First Medical University (CN)
- Hainan Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1186/s12866-025-03892-x
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Natural Science Foundation of China