Gut microbiome and short-chain fatty acids associated with the efficacy of growth hormone treatment in children with short stature
GHD, ISS, and healthy children have different fecal microbiota compositions and SCFA metabolisms. rhGH therapy partially restores microbial balance and alters metabolic pathways, with SCFA levels associated with treatment efficacy. These findings highlight the gut microbiome as a potential modulator of rhGH response and provide insight into microbiota-targeted therapies to improve growth outcomes (e.g., "probiotic interventions").
Authors
- Liang Zhang (ORCID: https://orcid.org/0000-0002-0454-8001)
- Yongfen Lyu
- Liya Xu (ORCID: https://orcid.org/0000-0002-5501-2039)
- Yan Li (ORCID: https://orcid.org/0000-0001-7612-3953)
- Wenxin Liu (ORCID: https://orcid.org/0000-0003-4137-8686)
- Ying Zhang (ORCID: https://orcid.org/0000-0001-6394-3231)
- Yuying Huang (ORCID: https://orcid.org/0000-0003-1208-5980)
- Xinyuan Shen
- Pingsihua He
- Sheng Guo
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Children's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-03-31
- DOI
- https://doi.org/10.3389/fped.2025.1557878
- Citations
- 2
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 2.33