IFN-γ-Induced intestinal epithelial cell-type-specific programmed cell death: PANoptosis and its modulation in Crohn’s disease
IFN-γ induces PANoptosis in enterocytes, which can be treated with a selective JAK1 inhibitor in patients with CD.
Authors
- Ji Hwan Moon (ORCID: https://orcid.org/0000-0002-0172-4428)
- Dong Kyung Chang (ORCID: https://orcid.org/0000-0001-8925-4629)
- Eun Ran Kim (ORCID: https://orcid.org/0000-0002-0495-2565)
- Chansu Lee (ORCID: https://orcid.org/0000-0003-3992-9645)
- Young Ho Kim (ORCID: https://orcid.org/0000-0002-5281-1185)
- Ji Eun Kim (ORCID: https://orcid.org/0000-0002-0108-6016)
- Sung Noh Hong
- Yeo-Eun Cha
Institutions
- Samsung Medical Center (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-31
- DOI
- https://doi.org/10.3389/fimmu.2025.1523984
- Citations
- 9
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- National Research Foundation of Korea