BAM8-22 targets spinal MrgC receptors to modulate UPRmt activity in the mechanism of bone cancer pain
By activating spinal MrgC to mediate UPR<sup>mt</sup> activity and protect mitochondrial function, BAM8-22 contributes to the molecular development of BCP. This discovery suggests a new therapeutic target for BCP and offers a possible research avenue.
Authors
- Rui Xu (ORCID: https://orcid.org/0000-0001-9459-6738)
- Dan Li (ORCID: https://orcid.org/0000-0002-3988-3483)
- Jiacheng Yu (ORCID: https://orcid.org/0009-0000-2588-0428)
- Zhen Wang (ORCID: https://orcid.org/0000-0003-4134-1779)
- Hao Zeng (ORCID: https://orcid.org/0000-0002-1267-0509)
- Yue Sun (ORCID: https://orcid.org/0000-0001-6348-4549)
- Yu-Lin Huang (ORCID: https://orcid.org/0000-0001-5018-8767)
- Mingming Xie
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Drum Tower Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-31
- DOI
- https://doi.org/10.3389/fphar.2025.1575733
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China