The TLR-M-CSF axis is implicated in increased bone turnover and curve progression in adolescent idiopathic scoliosis
Together, our findings suggest that the TLR-M-CSF axis is implicated in osteoclastogenesis, resulting in increased bone turnover and may contribute to curve progression in AIS patients.
Authors
- Svetlana V. Komarova (ORCID: https://orcid.org/0000-0003-3570-3147)
- Lisbet Haglund (ORCID: https://orcid.org/0000-0002-1288-2149)
- Daniel G. Bisson (ORCID: https://orcid.org/0000-0003-4812-059X)
- Neil Saran (ORCID: https://orcid.org/0000-0002-7491-9234)
- Kerstin Tiedemann (ORCID: https://orcid.org/0000-0001-5210-722X)
- Jean Ouellet (ORCID: https://orcid.org/0000-0003-0092-4935)
- Kai Sheng (ORCID: https://orcid.org/0000-0002-9236-3663)
- Jake Bourdages
- Christopher A Coluni
- Kirby Upshaw
Institutions
- University of Alberta (CA)
- McGill University Health Centre (CA)
- Shriners Hospitals for Children - Canada (CA)
- McGill University (CA)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1186/s13075-025-03535-6
- Citations
- 2
- Primary Topic
- Scoliosis diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé