The CXCR3/PLC/IP3-IP3R axis is responsible for the ignition of UPR in intestinal epithelial cells exposed to gliadin peptide, during the onset of celiac disease
The PT-dependent ER stress observed in the IECs of CD patients results from the excessive release of calcium from the ER. Importantly, inhibition of this signaling pathway abrogates ER stress, which in turn attenuates downstream signs of CD, such as TG2 expression and gut permeability dysregulation, as well as inhibits inflammation.
Authors
- Mara Gagliardi (ORCID: https://orcid.org/0000-0002-3222-790X)
- Ivana Rabbone (ORCID: https://orcid.org/0000-0003-4173-146X)
- Alice Monzani (ORCID: https://orcid.org/0000-0002-6676-5773)
- Marco Corazzari (ORCID: https://orcid.org/0000-0002-6246-5968)
- Valentina Saverio (ORCID: https://orcid.org/0000-0002-1770-2661)
- Romina Monzani (ORCID: https://orcid.org/0000-0001-9750-8342)
- Silvia Saettone
- Daniele Sblattero (ORCID: https://orcid.org/0000-0003-4309-242X)
- Luigina De Leo (ORCID: https://orcid.org/0000-0003-4013-1630)
- Nausicaa Clemente (ORCID: https://orcid.org/0000-0002-9860-0148)
- Nico Pagano (ORCID: https://orcid.org/0000-0002-0626-4563)
- Dmitry Lim (ORCID: https://orcid.org/0000-0002-4316-2654)
- Francesca Nigrelli
- Emanuele Ferrario
- Samuele Pellizzaro
Institutions
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- University of Trieste (IT)
- IRCCS Materno Infantile Burlo Garofolo (IT)
- Azienda Ospedaliero Universitaria Maggiore della Carita (IT)
Publication Details
- Journal
- Biology Direct
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1186/s13062-025-00633-y
- Citations
- 2
- Primary Topic
- Celiac Disease Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 3.62