The protective role of melatonin and agomelatine against oxidative stress following laparoscopic ovariectomy in dogs
The results of this study demonstrate that melatonin, by increasing total antioxidant capacity, and agomelatine, through enzymatic antioxidant pathways, contributed to the reduction of free radical levels in dogs. The present study revealed that administering agomelatine (0.3 mg/kg/day, p.o) could decrease MDA levels significantly after laparoscopic ovariectomy up to day 3.
Authors
- Hossein Kazemi Mehrjerdi (ORCID: https://orcid.org/0000-0002-5593-6864)
- Shahrzad Azizi (ORCID: https://orcid.org/0000-0003-3746-9593)
- Mahdieh Zaeemi (ORCID: https://orcid.org/0000-0002-4226-8393)
Institutions
- Ferdowsi University of Mashhad (IR)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1186/s12917-025-04671-6
- Citations
- 2
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 1.83