Comparison of the efficacy of ultrasound-guided dextrose 25% hypertonic prolotherapy and intra-articular normal saline injection on pain, functional limitation, and range of motion in patients with knee osteoarthritis; a randomized controlled trial

Although we achieved slightly better results with DPTx, this treatment technique was not clinically or statistically superior to IA-NS in terms of knee pain and function in the short-term. Therefore, both DPTx and IA-NS are effective and well tolerated treatment options for knee OA. However, more RCTs are needed to confirm these claims.