The Interaction Between <i>Ganoderma lucidum</i> Polysaccharides and Gut Microbiota: Implications for Immune Health

Ganoderma lucidum polysaccharides (GLPs) are natural polysaccharide compounds extracted from Ganoderma lucidum, known for their diverse biological activities.This study explores the interaction between GLPs and gut microbiota and its effects on immune health, revealing how GLPs regulate immune responses through gut microbiota and investigating their potential applications in preventing and treating immune-related diseases.The study shows that GLPs can increase the production of short-chain fatty acids, regulate the proportion of beneficial gut bacteria, and alleviate inflammatory responses by modulating the TLR4/MyD88/NF-B signaling pathway.The results indicate that GLPs significantly improve gut microbiota imbalance, enhance macrophage phagocytosis, and increase the cytotoxicity of natural killer cells, demonstrating their potential in immune regulation and disease prevention.Future research will focus on further uncovering the molecular mechanisms of GLPs and their long-term application potential in human health.