RO5126766 attenuates osteoarthritis by inhibiting osteoclastogenesis and protecting chondrocytes through mediating the ERK pathway
In this study, we have, for the first time, substantiated the therapeutic potential of RO in the treatment of OA. By demonstrating its ability to inhibit osteoclast differentiation and protect articular cartilage, RO could offer a new avenue for disease-modifying treatments in OA. Thus, this paper provides valuable insights into understanding the molecular mechanisms and treatment of OA.
Authors
- Rong Shen (ORCID: https://orcid.org/0000-0002-7155-1876)
- Guixin Yuan (ORCID: https://orcid.org/0000-0001-5996-5497)
- Zuoxing Wu
- Xiao Yuan (ORCID: https://orcid.org/0009-0004-9805-349X)
- Zemin Ling (ORCID: https://orcid.org/0000-0002-2742-6429)
- Ren Xu (ORCID: https://orcid.org/0000-0001-6578-4553)
- Lin Meng (ORCID: https://orcid.org/0000-0003-4351-6923)
- Chenyang Guo (ORCID: https://orcid.org/0009-0007-1628-6794)
- Zihan Chen (ORCID: https://orcid.org/0009-0007-8387-5687)
- Fan Shi (ORCID: https://orcid.org/0000-0002-6839-9017)
- Xuemei He (ORCID: https://orcid.org/0000-0002-1092-2784)
- Jie Han (ORCID: https://orcid.org/0000-0001-7560-8967)
- Jianming Huang (ORCID: https://orcid.org/0000-0002-8123-2027)
- Zhengqiong Luo
- Ziyao Ma (ORCID: https://orcid.org/0009-0006-7232-8648)
- Han Wang (ORCID: https://orcid.org/0000-0001-5888-8805)
Institutions
- Ritsumeikan University (JP)
- Sun Yat-sen University (CN)
- Xiamen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- 174th hospital of the People's Liberation Army (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-03-30
- DOI
- https://doi.org/10.1016/j.jot.2025.03.002
- Citations
- 4
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.22