Age differences in prefrontal cortex activity during dual-task tandem gait: An fNIRS study

Tandem Gait (TG) under dual-task (DT) conditions may facilitate the investigation of important aspects of dynamic balance and mobility, particularly concerning pathological motor and cognitive aging processes. Our study aims to identify age-related differences in behavioral and neural changes caused by interference during dual-task while TG. 20 young (YA, age 21.3 ± 1.86) and 12 middle-aged adults (MA, age 55.3 ± 3.81) had to perform TG cognitive tasks ((a) recite the alphabet backward, (b) recite numbers and letters alternately (oral TMT-B), and (c) count backward from a given 3-digit number in steps of 3), and DT (TG + cognitive tasks) for 30 s each. The cortical activation of the frontal lobe was recorded using an 8 sources × 8 detectors fNIRS system. On the behavioral data, MA displayed a notably reduced number of accurate motor responses compared to YA, though their cognitive responses remained comparable. From a neural perspective, the linear mixed model revealed significant task- and group-related interaction effects only in the left dorsal lateral PFC. Compared to YA, the MA showed lower activation over time during DT, which can be attributed to the limitation of neural resources in the frontal lobe. This downregulation may be due to overload, indicating that MA are approaching their neural resources' capacity limit, particularly when confronted with complex motor task demands.