The abnormal choline to creatine ratio of the right anterior cingulate gyrus is linked to cognitive impairment in youth with major depressive disorder
Our findings suggest that both CI and NCI MDD may experience putamen dysfunction. Additionally, the frequency of depressive episodes appears to have a cumulative effect on alterations in the Cho/Cr ratios in the putamen. Concurrently, an increased Cho/Cr ratio in the ACC is linked to widespread cognitive deficits in MDD patients. These results may point to a subgroup of patients who could benefit from interventions aimed at modulating brain functional status.
Authors
- Xiaodan Lu (ORCID: https://orcid.org/0000-0001-8554-6325)
- Sha Luo (ORCID: https://orcid.org/0000-0001-8942-8350)
- Jia L. Zhuo (ORCID: https://orcid.org/0000-0001-9477-9075)
- Jie Yın (ORCID: https://orcid.org/0009-0005-6513-4127)
- Dongxue Wei
- Linna Chu
- Jianzhao Zhang (ORCID: https://orcid.org/0000-0002-9367-173X)
- Shunkai Lai
- Xiaojie Ye (ORCID: https://orcid.org/0009-0001-9327-9930)
- Ying Wang (ORCID: https://orcid.org/0000-0003-4524-1812)
- Yong Zhang (ORCID: https://orcid.org/0000-0002-6355-9923)
- Pan Chen (ORCID: https://orcid.org/0000-0002-0339-3298)
- Yanbin Jia
- Shuming Zhong
- Meiqi Zhang (ORCID: https://orcid.org/0009-0009-4241-4862)
- Yikun Liang
- Munila Abula
Institutions
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2025-03-30
- DOI
- https://doi.org/10.1016/j.jad.2025.03.161
- Primary Topic
- Cardiovascular Syncope and Autonomic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00