Sphaeropsidin A covalently binds to Cys 151 of Keap1 to attenuate LPS-induced acute pneumonia in mice
This study indicates that SA might be a new covalent molecule of Keap1 to activate Nrf2, and is a promising drug candidate or lead molecule for the therapy of acute pneumonia through regulating Nrf2/NF-κB/NLRP3 inflammasome axis.
Authors
- Qingwen Hu
- Lin‐Tao Xu
- Lu-Zhou Chen
- Lan Xiang (ORCID: https://orcid.org/0000-0002-7149-8235)
- Dong‐Mei Ren (ORCID: https://orcid.org/0000-0002-1717-2429)
- Qing‐Tong Han
- Xiao‐Ning Wang (ORCID: https://orcid.org/0000-0001-5032-5135)
- Tao Shen (ORCID: https://orcid.org/0000-0001-5856-0818)
- Zhiying Li (ORCID: https://orcid.org/0000-0002-7296-7945)
- Rong-Xue Xing
- Kang Yang (ORCID: https://orcid.org/0009-0009-1868-2357)
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Redox Biology
- Published
- 2025-03-30
- DOI
- https://doi.org/10.1016/j.redox.2025.103621
- Citations
- 3
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 4.56