MicroRNA-124-3p and Brain-derived Neurotrophic Factor in Rat Spinal Cord Injury: Inverse Expression Pattern
Spinal cord injury (SCI) significantly impacts the central nervous system, with limited effective treatments available. Brain-derived neurotrophic factor (BDNF) plays a crucial role in neuronal growth, survival, and regeneration after SCI. MicroRNAs, particularly miR-124-3p, have been implicated in SCI pathophysiology. However, the relationship between miR-124-3p and BDNF in the context of SCI remains unclear. This study aimed to investigate the correlation between miR-124-3p expression and BDNF levels in a rat model of spinal cord injury and to assess how the timing of injury affects this relationship.
Authors
- Mehdi Sadegh (ORCID: https://orcid.org/0000-0001-5791-2463)
- Mahdieh Mondanizadeh
- Behzad Khansarinejad (ORCID: https://orcid.org/0000-0001-8898-307X)
- Maryam Zand (ORCID: https://orcid.org/0009-0005-5200-1499)
Publication Details
- Journal
- Gene Expression
- Published
- 2025-03-31
- DOI
- https://doi.org/10.14218/ge.2024.00073
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Arak University of Medical Sciences