Navigating challenges in pediatric trial conduct: integrating bayesian sequential design with semiparametric elicitation for handling primary and secondary endpoints
Our findings indicate that these methods are especially effective in managing the complexities of pediatric trials, where prior data may be limited or contradictory. The flexibility of Semiparametric prior design in incorporating new evidence proves advantageous in addressing recruitment challenges and making informed decisions with restricted data.
Authors
- Ileana Baldi (ORCID: https://orcid.org/0000-0002-8578-9164)
- Darío Gregori (ORCID: https://orcid.org/0000-0001-7906-0580)
- Silvia Bressan (ORCID: https://orcid.org/0000-0002-6736-5392)
- Paola Berchialla (ORCID: https://orcid.org/0000-0001-5835-5638)
- Liviana Da Dalt (ORCID: https://orcid.org/0000-0003-2977-3907)
- Mohd Rashid Khan
- Danila Azzolina (ORCID: https://orcid.org/0000-0002-8185-5742)
Institutions
- University of Padua (IT)
- University of Ferrara (IT)
- University of Turin (IT)
Publication Details
- Journal
- BMC Medical Research Methodology
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1186/s12874-025-02484-7
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Padova