Effect of Plasma Soluble Urokinase-Type Plasminogen Activator Receptor and Plasminogen Activator Inhibitor-1 Levels in the Plasma of Babylon Women with Breast Cancer

Abstract Background: Worldwide, the occurrence of breast cancer is elevated as well as the number of mortality in women cancers. The movement of cancer cells from the first stage and invasion of the surrounding tissue are called cancer metastasis. The fibrinolytic system, in the urokinase-type plasminogen activator system, is disturbed due to breast cancer. Objective: The education aim to estimate soluble urokinase-type plasminogen activator receptor (s-uPAR) and plasminogen activator inhibitor-1 (PAI-1) levels in the plasma of Babylon women with breast cancer and control groups. Materials and Methods: The case–control group was made up of 42 women (presumably healthy women), whereas the patient group was made up of 42 women with breast cancer. In plasma, the concentrations of s-uPAR and PAI-1 levels were estimated by enzyme-linked immunosorbent assay (ELISA), the statistical analysis was conducted by the SPSS software. Results: The result suggests that elevated in PAI-1 and s-uPAR levels, in the patients group compared with the control group ( P < 0.05). Conclusion: The women with breast cancer had elevated serum levels of PAI-1 and s-uPAR. Based on the results of this investigation, this indicate that PAI-1 and s-uPAR act as prognostic indicators in breast cancer women.